Symptoms spinal fluid leak11/11/2023 The extent and type of skull base repair depends on the size and location of the defect. Kelly’s Recent Experience, CSF leaks that occur at the time of surgery require careful repair to avoid a post-operative CSF leak. One of the more common complications of endonasal transsphenoidal surgery is a post-operative CSF leak. This is a potentially dangerous condition that can lead to an infection of the CSF (meningitis) or of the brain itself (brain abscess). On occasion, as a result of a skull fracture, weakness of the brain covering (dura), intracranial surgery or growth of a brain tumor, CSF may leak through the brain covering.
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